Polypill Variants (Quarter Pill Trials)

Haematological Changes Following Reining Trials in Quarter Horses

Background: It is well known that exercise induce physiological stress on horse’s body system, causing signifi cant changes in blood components. Haematological changes associated with exercise have been widely analyzed to provide information about health status and athletic performance in horses. Numerous studies have been performed to investigate the response of haematological parameters to va...

An International Randomised Placebo-Controlled Trial of a Four-Component Combination Pill (“Polypill”) in People with Raised Cardiovascular Risk

BACKGROUND There has been widespread interest in the potential of combination cardiovascular medications containing aspirin and agents to lower blood pressure and cholesterol ('polypills') to reduce cardiovascular disease. However, no reliable placebo-controlled data are available on both efficacy and tolerability. METHODS We conducted a randomised, double-blind placebo-controlled trial of a ...

Polypill: chimera or reality?

The idea of including several drugs in a fixed-dose combination for cardiovascular prevention was born at the beginning of this century. Although the suggestion initially received scant attention, the seminal work of Wald and Law in 2003, which introduced the term polypill, attracted the interest of researchers and the media, sparking a controversy that continues today. For some health professi...

Exercise is the real polypill.

The concept of a "polypill" is receiving growing attention to prevent cardiovascular disease. Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free intervention for which our genome has been haped over evolution. Compared with drugs, exercise is available at low cost and relatively free of adverse effects. We summarize epidemiological evidence on the preve...

Is Statin Monotherapy the Perfect Polypill?